Tumour evolution and microenvironment interactions in 2D and 3D space

Chia-Kuei Mo, Jingxian Liu, Siqi Chen, +42

Nature

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, +12

Nature Communications

TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability

Surbhi Chouhan, Mithila Sawant, Cody Weimholt, +6

Autophagy

Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma

Yige Wu, Nadezhda V. Terekhanova, Wagma Caravan, +39

Nature Communications

Histone H2A Lys130 acetylation epigenetically regulates androgen production in prostate cancer

Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, +11

Nature Communications

Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting

Mithila Sawant, Kiran Mahajan, Arun Renganathan, +13

Science Translational Medicine

Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor

Mithila Sawant, Audrey Wilson, Dhivya Sridaran, +10

Oncogene

Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer

Duy T. Nguyen, Wei Yang, Arun Renganathan, +8

Clinical Cancer Research