Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms

Ik Sun Kim, Yang Gao, Thomas Welte, +26

Nature Cell Biology

Breast OncologyCancer ImmunosurveillanceBreast Cancer RevealsMalignant Blood DisorderImmunology +9

The bone microenvironment invigorates metastatic seeds for further dissemination

Weijie Zhang, Igor Bado, Jingyuan Hu, +22

Cell

Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis

Yixian Wang, Zhan Xu, Kuan‐Lin Wu, +9

Proceedings of the National Academy of Sciences

Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential

Piti Techavichit, Yang Gao, Lyazat Kurenbekova, +3

BMC Cancer

Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal

Xiaoxin Hao, Yichao Shen, Nan Chen, +27

Cell stem cell

Tumor RemovalBone Morphogenic ProteinImmunologyImmunotherapyMedicine +4

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer

Liqun Yu, Keziah Liebenberg, Yichao Shen, +20

Immunity

Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Weijie Zhang, Zhan Xu, Xiaoxin Hao, +21

Cancer Discovery

Targeting eIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

Na Zhao, Elena B. Kabotyanski, Alexander B. Saltzman, +18

Journal of Clinical Investigation

Breast OncologyImmunologyMrna TranslationZotatifin TreatmentImmunoediting +17

Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

Yang Gao, Marina P. Volegova, Nicole Nasholm, +8

Frontiers in Oncology

Tumor Suppressor PLK2 May Serve as a Biomarker in Triple-Negative Breast Cancer for Improved Response to PLK1 Therapeutics

Yang Gao, Elena B. Kabotyanski, Jonathan H. Shepherd, +13

Cancer Research Communications