Xiaozhang Xu

Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells

Jian Gu, Jinren Zhou, Qiuyang Chen et al. · Cell Reports · 2022 · 470 citations · Full text

Medicine, Immunology, Oncology +17

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

Jian Gu, Xiaozhang Xu, Xiangyü Li et al. · Oncogene · 2024 · 113 citations · Full text

Life Sciences, Immunology, Oncology +17

Lactate supports Treg function and immune balance via MGAT1 effects on N-glycosylation in the mitochondria

Jinren Zhou, Jian Gu, Qufei Qian et al. · Journal of Clinical Investigation · 2024 · 53 citations · Full text

Life Sciences, Immunology, Molecular Biology +16

Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization

Lei Yue, Xiaozhang Xu, Shipeng Dai et al. · Scientific Reports · 2023 · 22 citations · Full text

Medicine, Cancer Biology, Oncology +17

Monocarboxylate transporter upregulation in induced regulatory T cells promotes resistance to anti-PD-1 therapy in hepatocellular carcinoma patients

Jinren Zhou, Qing Shao, Yunjie Lu et al. · Frontiers in Oncology · 2022 · 20 citations · Full text

Medicine, Immunology, Oncology +17