Matthew C. O’Reilly

Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells

Matthew C. O’Reilly, Sarah Scott, Kyle A. Brown et al. · Journal of Medicinal Chemistry · 2013 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR

Matthew C. O’Reilly, Shi‐Hui Dong, Francis M. Rossi et al. · Cell chemical biology · 2018 · 67 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of Desketoraloxifene Analogues as Inhibitors of Mammalian, <i>Pseudomonas aeruginosa</i>, and NAPE Phospholipase D Enzymes

Sarah Scott, C. Thomas Spencer, Matthew C. O’Reilly et al. · ACS Chemical Biology · 2014 · 48 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +9

Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the <i>Pseudomonas aeruginosa</i> Quorum Sensing Receptor LasR with Nanomolar IC₅₀ Values

Daniel E. Manson, Matthew C. O’Reilly, Kayleigh E. Nyffeler et al. · ACS Infectious Diseases · 2020 · 44 citations · Full text

Life Sciences, Medicinal Chemistry, Microbiology +17

Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor

Matthew C. O’Reilly, Helen E. Blackwell · ACS Infectious Diseases · 2015 · 38 citations · Full text

Pharmacy, Chemical Biology, Drug Design +14