Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms

Marito Araki, Yinjie Yang, Nami Masubuchi, +10

Blood

Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation

Marito Araki, Yinjie Yang, Misa Imai, +9

Leukemia

Protein FunctionBiochemistryProtein AssemblyProtein FoldingMpl Binding +8

Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9

Seiko Yoshino, Takashi Yokoyama, Yoshitaka Sunami, +6

Blood

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

C. Pecquet, Nicolas Papadopoulos, Thomas Balligand, +39

Blood

PathologyMolecular BiologyCytoskeletonMutant CalrCancer Biology +18

JAK2V617F mutation status and allele burden in classical Ph-negative myeloproliferative neoplasms in Japan

Yoko Edahiro, Soji Morishita, Kochi Takahashi, +15

International Journal of Hematology

Hematological MalignancyJak2v617f Mutation StatusGeneticsMedicineHematology +3

Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells

Yoshitaka Sunami, Marito Araki, Yumi Hironaka, +7

PLoS ONE

BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes

Yoshitaka Sunami, Takashi Yokoyama, Seiko Yoshino, +4

Blood Advances

Mixed-phenotype Acute LeukemiaTranscriptional Repressor Bcl11aImmunologyTumor BiologyMyeloid Neoplasia +14

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

C. Pecquet, Thomas Balligand, Ilyas Chachoua, +27

Blood

Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential thrombocythemia

Shuichi Shirane, Marito Araki, Soji Morishita, +8

International Journal of Hematology

InflammationThrombosisPolycythemia VeraHematological MalignancyBone Marrow Failure +6

Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells

Yoshitaka Sunami, Marito Araki, Shin Kan, +6

Journal of Biological Chemistry

Hematological MalignancyChromatinCell RegulationChromatin RemodelingCell Signaling +7