Carmen Baquero

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

Xueqian Gong, Lacey M. Litchfield, Yue Webster et al. · Cancer Cell · 2017 · 236 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the <i>RB1</i> Tumor Suppressor Gene

Xueqian Gong, Jian Du, Stephen H. Parsons et al. · Cancer Discovery · 2018 · 233 citations

Life Sciences, Oncology, Pharmacology +17

Preclinical characterization of abemaciclib in hormone receptor positive breast cancer

Raquel Torres-Guzmán, Bruna Calsina, Ana Hermoso et al. · Oncotarget · 2017 · 198 citations · Full text

Medicine, Oncology, Pharmacology +17

Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Jian Du, Lei Yan, Raquel Torres et al. · Molecular Cancer Therapeutics · 2019 · 52 citations · Full text

Medicine, Oncology, Pharmacology +15

Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy

Severine Gharbi, Laura A. Pelletier, Alfonso Espada et al. · npj Breast Cancer · 2022 · 28 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16