Coagulation factor V and thrombophilia: Background and mechanisms

Kenneth Segers, Björn Dahlbäck, Gerry A. F. Nicolaes

Thrombosis and Haemostasis

ImmunologyPathologyThrombosisVenous ThrombosisHematology +15

Design of protein–membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V

Kenneth Segers, Olivier Spérandio, M. Sack, +5

Proceedings of the National Academy of Sciences

Proteinlipid InteractionDrug TargetFactor VMedicinal ChemistryMolecular Recognition +16

Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors

Miyeon Jang, Steven De Jonghe, Kenneth Segers, +2

Bioorganic & Medicinal Chemistry

Antimicrobial Drug DiscoveryE. ColiBiochemistryMedicineSeca Inhibitors +7

Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation

Samira Jeimy, Nola Fuller, Subia Tasneem, +6

Thrombosis and Haemostasis

The Role of Thrombin Exosites I and II in the Activation of Human Coagulation Factor V

Kenneth Segers, Björn Dahlbäck, Paul Bock, +3

Journal of Biological Chemistry

ImmunologyMolecular BiologyThrombin Exosite IiThrombin ExositesThrombosis +14

Defining the structure of membrane‐bound human blood coagulation factor Va

Svetla Stoilova‐McPhie, Christopher Parmenter, Kenneth Segers, +2

Journal of Thrombosis and Haemostasis

Development of a high-throughput screening assay for the discovery of small-molecule SecA inhibitors

Kenneth Segers, Hugo Klaassen, Anastassios Economou, +2

Analytical Biochemistry

Small-molecule Seca InhibitorsMedicinal ChemistryBiochemistryMedicineNatural Sciences +10

Structural models of the snake venom factor V activators from <i>Daboia russelli</i> and <i>Daboia lebetina</i>

Kenneth Segers, Jan Rosing, Gerry A. F. Nicolaes

Proteins Structure Function and Bioinformatics

Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening

Evelien De Waelheyns, Kenneth Segers, Marios Frantzeskos Sardis, +3

The Journal of Antibiotics

Molecular RecognitionMedicinal ChemistryVirtual ScreeningDrug TargetNatural Sciences +10

Screening Outside the Catalytic Site: Inhibition of Macromolecular Interactions Through Structure-Based Virtual Ligand Screening Experiments

Olivier Spérandio, Maria A. Miteva, Kenneth Segers, +2

The Open Biochemistry Journal

Proteinlipid InteractionDrug TargetMolecular BiologyChemical BiologyMolecular Recognition +17