James S. Frazee

SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

Eliot H. Ohlstein, P Nambi, Stephen A. Douglas et al. · Proceedings of the National Academy of Sciences · 1994 · 163 citations · Full text

Hypertension, Vascular Disease, Receptor Antagonist +21

Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake

Fadia E. Ali, William E. Bondinell, Penelope A. Dandridge et al. · Journal of Medicinal Chemistry · 1985 · 130 citations · Full text

Pharmacotherapy, Experimental Pharmacology, Molecular Pharmacology +16

Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine .beta.-hydroxylase. 4. Structure-activity relationships at the copper binding site

Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf et al. · Journal of Medicinal Chemistry · 1990 · 47 citations · Full text

Multisubstrate inhibitors of dopamine .beta.-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site

Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf et al. · Journal of Medicinal Chemistry · 1987 · 45 citations · Full text

Drug Target, Pharmacotherapy, Chemical Biology +19

Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P1′-P2′ amide bond isostere

Scott K. Thompson, Alecia M. Eppley, James S. Frazee et al. · Bioorganic & Medicinal Chemistry Letters · 1994 · 45 citations

Medicinal Chemistry, Biochemistry, Antiviral Activity +12