SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

Eliot H. Ohlstein, P Nambi, Stephen A. Douglas, +7

Proceedings of the National Academy of Sciences

HypertensionVascular DiseaseReceptor AntagonistPharmacotherapyExperimental Pharmacology +19

Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake

Fadia E. Ali, William E. Bondinell, Penelope A. Dandridge, +15

Journal of Medicinal Chemistry

PharmacotherapyExperimental PharmacologyMolecular PharmacologyMedicinal ChemistryGaba Uptake +14

Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine .beta.-hydroxylase. 4. Structure-activity relationships at the copper binding site

Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf, +6

Journal of Medicinal Chemistry

Multisubstrate inhibitors of dopamine .beta.-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site

Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf, +6

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +17

Synthesis and antiviral activity of a novel class of HIV-1 protease inhibitors containing a heterocyclic P1′-P2′ amide bond isostere

Scott K. Thompson, Alecia M. Eppley, James S. Frazee, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryAntiviral ActivityMedicineNatural Sciences +10

High-affinity leukotriene receptor antagonists. Synthesis and pharmacological characterization of 2-hydroxy-3-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl]propanoic acid

John G. Gleason, Ralph F. Hall, Carl D. Perchonock, +6

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmacological CharacterizationBiochemistryMedicine +12

Stereospecific synthesis of C-6(7) methoxypenicillin and cephalosporin derivatives

Timothy Jen, James S. Frazee, John R. E. Hoover

The Journal of Organic Chemistry

Antimicrobial Drug DiscoveryBioorganic ChemistryAntibioticsBiochemistryMedicine +12

Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors

Marlys Hammond, David G. Washburn, Tram H. Hoang, +17

Bioorganic & Medicinal Chemistry Letters

Bioavailable SerumMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +9

Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine .beta.-hydroxylase

Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf, +6

Journal of Medicinal Chemistry

Drug TargetAltmetric Attention ScorePharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +16

Multisubstrate inhibitors of dopamine .beta.-hydroxylase. 1. Some 1-phenyl and 1-phenyl-bridged derivatives of imidazole-2-thione

Lawrence I. Kruse, Carl Kaiser, Walter E. DeWolf, +7

Journal of Medicinal Chemistry