Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

Lijun Wang, Xiuling You, Sutada Lotinun, +3

Nature Communications

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

Matthew B. Greenblatt, Jae‐Hyuck Shim, Weiguo Zou, +14

Journal of Clinical Investigation

Caloric restriction leads to high marrow adiposity and low bone mass in growing mice

Maureen J. Devlin, Alison Cloutier, Nishina A. Thomas, +6

Journal of Bone and Mineral Research

NutritionSerum LeptinHigh Marrow AdiposityMetabolic DisorderCaloric Restriction +15

Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation

Yanqiu Liu, Agnes D. Berendsen, Shidong Jia, +4

Journal of Clinical Investigation

SclerostinConditional Vegf DeficiencyStem Cell BiologyOsteoporosisBone Morphogenic Protein +16

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

Sutada Lotinun, Riku Kiviranta, Takuma Matsubara, +9

Journal of Clinical Investigation

SclerostinDevelopmental BiologySignal TransductionBone ResorptionBone Morphogenic Protein +12

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin

Petra Šimić, Kayvan Zainabadi, Eric L. Bell, +7

EMBO Molecular Medicine

Mesenchymal Stem CellsDevelopmental BiologyMedicineNatural SciencesStem Cells +8

Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH

Vaibhav Saini, Dean A. Marengi, Kevin J. Barry, +8

Journal of Biological Chemistry

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

Vionnie W.C. Yu, Borja Sáez, Colleen Cook, +12

The Journal of Experimental Medicine

Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling

Keertik Fulzele, Daniela S. Krause, Cristina Panaroni, +13

Blood

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

Sutada Lotinun, R. Scott Pearsall, Monique V. Davies, +9

Bone

SclerostinCynomolgus MonkeysBone Morphogenic ProteinMedicinePhysiology +7