David J. Dowling

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

David J. Dowling, Evan A. Scott, Annette Scheid et al. · Journal of Allergy and Clinical Immunology · 2017 · 147 citations · Full text

Pharmacy, Immunology, Pharmaceutics +17

Major Secretory Antigens of the Helminth <i>Fasciola hepatica</i> Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses

David J. Dowling, C.M. Hamilton, Sheila Donnelly et al. · Infection and Immunity · 2009 · 126 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

Francesco Borriello, Valentina Poli, Ellen Shrock et al. · Cell · 2022 · 123 citations · Full text

Life Sciences, Immunology, Microbiology +17

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

Victoria J. Philbin, David J. Dowling, Leighanne C. Gallington et al. · Journal of Allergy and Clinical Immunology · 2012 · 122 citations · Full text

Life Sciences, Immunology, Pharmacology +16

AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen et al. · Scientific Reports · 2024 · 120 citations · Full text

Pharmacy, Bioinformatics, Medicinal Chemistry +16