David J. Dowling

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses

David J. Dowling, Evan A. Scott, Annette Scheid et al. · Journal of Allergy and Clinical Immunology · 2017 · 141 citations · Full text

Major Secretory Antigens of the Helminth <i>Fasciola hepatica</i> Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses

David J. Dowling, C.M. Hamilton, Sheila Donnelly et al. · Infection and Immunity · 2009 · 122 citations · Full text

Innate Immune System, Immunology, Immune Regulation +23

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

Victoria J. Philbin, David J. Dowling, Leighanne C. Gallington et al. · Journal of Allergy and Clinical Immunology · 2012 · 121 citations · Full text

Caspase-1–dependent Pathways, Innate Immune System, Immune Regulation +17

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity

Francesco Borriello, Valentina Poli, Ellen Shrock et al. · Cell · 2022 · 116 citations · Full text

Vaccination, Mucosal Vaccination, Microbial Pathogens +11

The<i>Fasciola hepatica</i>Tegumental Antigen Suppresses Dendritic Cell Maturation and Function

C.M. Hamilton, David J. Dowling, Christine E. Loscher et al. · Infection and Immunity · 2009 · 110 citations · Full text

Innate Immune System, Immunology, Immune Regulation +21