Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

Julian Stingele, Roberto Bellelli, Ferdinand Alte, +9

Molecular Cell

ChromatinGenome InstabilityCross-linkMedicineGenetics +13

TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding

Grzegorz Sarek, Jean‐Baptiste Vannier, Stephanie Panier, +2

Molecular Cell

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas

Grzegorz Sarek, Sari Kurki, Juulia Enbäck, +5

Journal of Clinical Investigation

KSHV-Initiated Notch Activation Leads to Membrane-Type-1 Matrix Metalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition

Fang Cheng, Pirita Pekkonen, Simonas Laurinavičius, +15

Cell Host & Microbe

A Recessive Founder Mutation in Regulator of Telomere Elongation Helicase 1, RTEL1, Underlies Severe Immunodeficiency and Features of Hoyeraal Hreidarsson Syndrome

Bari J. Ballew, Joseph Vijai, Saurav De, +21

PLoS Genetics

ChromatinGenome InstabilityMendelian DisorderSevere ImmunodeficiencyGenetic Disorder +12

Oncoprotein <scp>CIP</scp> 2A is stabilized via interaction with tumor suppressor <scp>PP</scp> 2A/B56

Jiao Wang, Juha Okkeri, Karolina Pavic, +8

EMBO Reports

Signal TransductionCell RegulationOncogenic AgentMedicineCell Biology +5

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Grzegorz Sarek, Panagiotis Kotsantis, Phil Ruis, +9

Nature

T-loop DynamicsSignal TransductionSignaling PathwayCell DivisionCell Regulation +9

Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency

Grzegorz Sarek, Annika Järviluoma, Henna M. Moore, +5

PLoS Pathogens

Viral ReplicationMolecular BiologyPathologySarcoma HerpesvirusCellular Physiology +16

KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas

Grzegorz Sarek, Annika Järviluoma, Päivi M. Ojala

Blood

Phosphorylation of the Cyclin-Dependent Kinase Inhibitor p21^Cip1 on Serine 130 Is Essential for Viral Cyclin-Mediated Bypass of a p21^Cip1-Imposed G₁ Arrest

Annika Järviluoma, Emma S. Child, Grzegorz Sarek, +4

Molecular and Cellular Biology

Serine 130Viral Cyclin-mediated BypassImmunologyTumor BiologyCancer-associated Virus +14