Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

Jason S. Seidman, Ty D. Troutman, Mashito Sakai, +20

Immunity

ChromatinLineage PlasticityEpigenetic ChangeGeneticsLiver Physiology +8

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Mashito Sakai, Ty D. Troutman, Jason S. Seidman, +19

Immunity

Induced Pluripotent Stem CellDevelopmental BiologyCell RegulationStem Cell ResearchGene Expression +6

Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study

Jianxin Shi, Xing Hua, Bin Zhu, +30

PLoS Medicine

Human microglia maturation is underpinned by specific gene regulatory networks

Claudia Z. Han, Rick Z. Li, Emily A. Hansen, +32

Immunity

Rare germline variants in known melanoma susceptibility genes in familial melanoma

Alisa M. Goldstein, Yanzi Xiao, Joshua N. Sampson, +21

Human Molecular Genetics

GeneticsGenetic EpidemiologyPathologyMolecular GeneticsGenomics +16

Multiple rare variants in high-risk pancreatic cancer-related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations

Xiaohong R. Yang, Melissa Rotunno, Yanzi Xiao, +29

Human Genetics

Pancreatic CancerMedicineGeneticsGermline Cdkn2a MutationsGenetic Epidemiology +6

Purification of mouse hepatic non-parenchymal cells or nuclei for use in ChIP-seq and other next-generation sequencing approaches

Ty D. Troutman, Hunter Bennett, Mashito Sakai, +3

STAR Protocols

EngineeringImmunologyImmunophenotypingTranscriptomics TechnologyImmunotherapy +19

Rare Germline Copy Number Variations and Disease Susceptibility in Familial Melanoma

Jianxin Shi, Weiyin Zhou, Bin Zhu, +19

Journal of Investigative Dermatology

Disease SusceptibilityGenetic DisorderMedicineGeneticsMelanoma +8

Characterization of Genomic Alterations in Radiation-Associated Breast Cancer among Childhood Cancer Survivors, Using Comparative Genomic Hybridization (CGH) Arrays

Xiaohong R. Yang, J. Keith Killian, Sue Hammond, +13

PLoS ONE

Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes

Hunter Bennett, Ty D. Troutman, Enchen Zhou, +12

Nature Immunology