Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

Fred W. Turek, Corinne E. Joshu, Akira Kohsaka, +10

Science

Homeostatic MechanismPacemaker NeuronsClock Transcription FactorObesityMetabolic Syndrome +18

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Akira Kohsaka, Aaron D. Laposky, Kathryn Moynihan Ramsey, +5

Cell Metabolism

ObesityMetabolic SyndromeNutritionEnergy HomeostasisAppetite Control +9

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Biliana Marcheva, Kathryn Moynihan Ramsey, Ethan D. Buhr, +15

Nature

BiochemistryClock Components ClockNatural SciencesPhysiologyDiabetes +7

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

Kathryn Moynihan Ramsey, Jun Yoshino, Cynthia S. Brace, +10

Science

Clock Gene Per2Homeostatic MechanismMolecular BiologyCryptochromeCircadian Clock +15

Circadian Timing of Food Intake Contributes to Weight Gain

Deanna M. Arble, Joseph Bass, Aaron D. Laposky, +2

Obesity

NutritionNocturnal MiceObesityMetabolic SyndromeBody Composition +15

Circadian Clock NAD ⁺ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Clara Bien Peek, Alison H. Affinati, Kathryn Moynihan Ramsey, +16

Science

Mitochondrial BiologyRedox BiologyOxidative StressBiosynthesisMitochondrial Oxidative Metabolism +20

Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle

Clara Bien Peek, Daniel C. Levine, Jonathan Cedernaes, +7

Cell Metabolism

Energy MetabolismCircadian Clock InteractionChronobiologyBiochemistrySkeletal Muscle +10

Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

Mark Perelis, Biliana Marcheva, Kathryn Moynihan Ramsey, +12

Science

Molecular ClockInsulin SignalingMetabolic SyndromeTranscriptional RegulationCellular Regulatory Mechanism +18

Alanine Scanning Mutagenesis of Insulin

Claus Kristensen, Thomas Kjeldsen, Finn C. Wiberg, +6

Journal of Biological Chemistry

Altered sleep regulation in leptin-deficient mice

Aaron D. Laposky, Jonathan Shelton, Joseph Bass, +3

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Sleep DisordersGeneticsSocial SciencesAltered Sleep RegulationHypothalamic Peptide +15