Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

Teresa G. Krieger, Stephan M. Tirier, Jeongbin Park, +6

Neuro-Oncology

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics

Stephan M. Tirier, Jan‐Philipp Mallm, Simon Steiger, +17

Nature Communications

A variable homopolymeric G-repeat defines small RNA-mediated posttranscriptional regulation of a chemotaxis receptor in <i>Helicobacter pylori</i>

Sandy R. Pernitzsch, Stephan M. Tirier, Dagmar Beier, +1

Proceedings of the National Academy of Sciences

Microbial PathogensWhereas Repg SrnaMolecular BiologyChemotaxis ReceptorTranscriptional Regulation +14

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, +20

Blood

Mixed-phenotype Acute LeukemiaImmunologyMultiomicsEpigeneticsTumor Biology +23

Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation

Murat Ö. Balaban, Patrick Bättig, Sandra Muschiol, +4

Proceedings of the National Academy of Sciences

Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level

Lukas John, Alexandra M. Poos, Alexander Brobeil, +35

Nature Communications

Pronounced HeterogeneityEngineeringImmunologyBiological MicroenvironmentsImmunotherapy +23

ALT-FISH quantifies alternative lengthening of telomeres activity by imaging of single-stranded repeats

Lukas Frank, Anne Rademacher, Norbert Mücke, +9

Nucleic Acids Research

EngineeringGeneticsMolecular GeneticsCancer BiologySingle-stranded Repeats +19

Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer

Martina K. Zowada, Stephan M. Tirier, Sebastian M. Dieter, +19

Cancers

Systems BiologyOncologyHuman CrcSingle Cell SequencingMedicine +12

Pheno-seq – linking visual features and gene expression in 3D cell culture systems

Stephan M. Tirier, Jeongbin Park, Friedrich Preußer, +16

Scientific Reports

Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

David R. Ghasemi, Konstantin Okonechnikov, Anne Rademacher, +23

Nature Communications