Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

Kimberly J. Van Zee, Tadahiko Kohno, E Fischer, +3

Proceedings of the National Academy of Sciences

ImmunologyImmune RegulationPathologyCell DeathClinical Inflammation +18

T-cell co-stimulation through B7RP-1 and ICOS

Steven K. Yoshinaga, John Whoriskey, Sanjay D. Khare, +23

Nature

T-cell Co-stimulationSignal TransductionAdaptive Immune SystemT-regulatory CellImmunology +5

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

Kien T. Nguyen, Terrence Deak, Stephanie M. Owens, +4

Journal of Neuroscience

ImmunologyPeripheral Immune StimulationGlucocorticoidSocial SciencesNeuroinflammation +16

Apolipoprotein A-I inhibits the production of interleukin-1β and tumor necrosis factor-α by blocking contact-mediated activation of monocytes by T lymphocytes

Nevila Hyka, Jean‐Michel Dayer, Christine Modoux, +4

Blood

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

Tadahiko Kohno, Michael Brewer, S.L. Baker, +6

Proceedings of the National Academy of Sciences

InflammationCytokineAnti-inflammatoryAutoimmune DiseaseMedicine +13

Identification and Characterization of a Pro-tumor Necrosis Factor-α-processing Enzyme from the ADAM Family of Zinc Metalloproteases

Mary S. Rosendahl, Si‐Hwan Ko, Dana L. Long, +10

Journal of Biological Chemistry

Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I

Krzysztof Selmaj, W Papierz, Andrzej Głąbiński, +1

Journal of Neuroimmunology

AllergyAutoimmune DiseaseImmunologyExperimental Autoimmune EncephalomyelitisAutoimmunity +6

Structures of the extracellular domain of the type I tumor necrosis factor receptor

James H. Naismith, Tracey Q. Devine, Tadahiko Kohno, +1

Structure

InflammationSignal TransductionExtracellular DomainImmunologyReceptor (Biochemistry) +9

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

Steven K. Yoshinaga, Ming Zhang, Jeanne Pistillo, +13

International Immunology

ImmunologyImmune RegulationMolecular BiologyImmunologic MechanismInflammation +16

Enzyme Evolution: Generation of a Bifunctional Enzyme by Fusion of Adjacent Genes

Joseph Yourno, Tadahiko Kohno, John R. Roth

Nature

Cellular EnzymologyBiochemistryNatural SciencesEnzyme CatalysisDirected Evolution +7