A YAC Mouse Model for Huntington’s Disease with Full-Length Mutant Huntingtin, Cytoplasmic Toxicity, and Selective Striatal Neurodegeneration

John Hodgson, N. Agopyan, Claire‐Anne Gutekunst, +16

Neuron

Neurodegenerative DiseasesFull-length Mutant HuntingtinSelective Striatal NeurodegenerationGeneticsYac Mouse Model +6

Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin

Rona K. Graham, Yu Deng, Elizabeth Slow, +15

Cell

Neurodegenerative DiseasesDevelopmental BiologyMolecular NeuroscienceSignal TransductionCell Death +8

ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation

Cheryl L. Wellington, E Walker, Agripina Suarez, +10

Laboratory Investigation

Transcriptional RegulationFunctional GenomicsMolecular RegulationAbca1 MrnaGenetics +8

Absence of behavioral abnormalities and neurodegeneration<i>in vivo</i>despite widespread neuronal huntingtin inclusions

Elizabeth Slow, Rona K. Graham, Alexander P. Osmand, +9

Proceedings of the National Academy of Sciences

Increased ABCA1 activity protects against atherosclerosis

Roshni R. Singaraja, Catherine Fiévet, Graciela Castro, +9

Journal of Clinical Investigation

Increased ABCA1 activity protects against atherosclerosis

Roshni R. Singaraja, Catherine Fiévet, Graciela Castro, +9

Journal of Clinical Investigation

Abc Transporter Abca1Vascular DiseaseImmunologyHyperlipidemiaInflammation +18

Human ABCA1 BAC Transgenic Mice Show Increased High Density Lipoprotein Cholesterol and ApoAI-dependent Efflux Stimulated by an Internal Promoter Containing Liver X Receptor Response Elements in Intron 1

Roshni R. Singaraja, Virginie Bocher, E. James, +14

Journal of Biological Chemistry

Transcriptional RegulationSystems BiologyMolecular PhysiologyIntron 1Abca1 Protein +11

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

Jeremy M. Van Raamsdonk, Jacqueline Pearson, Daniel A. Rogers, +4

Human Molecular Genetics

Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function

Joanna M. Karasinska, Franz Rinninger, Dieter Lütjohann, +12

Journal of Neuroscience

Specific LossOxysterolBiochemistryInfluences Neuronal StructurePhysiology +12

<i>Als2</i> -deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

Rebecca S. Devon, Paul C. Orban, Kimberly Gerrow, +16

Proceedings of the National Academy of Sciences

Motor Control DisordersEndosome TraffickingCell DeathAlsin-null MiceSynaptic Signaling +14