Harold E. Van Wart

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

Harold E. Van Wart, Henning Birkedal‐Hansen · Proceedings of the National Academy of Sciences · 1990 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +16

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

Eric B. Springman, Eddie L. Angleton, Henning Birkedal‐Hansen et al. · Proceedings of the National Academy of Sciences · 1990 · 712 citations

Life Sciences, Biochemistry, Molecular Biology +13

Hydrolysis of a Broad Spectrum of Extracellular Matrix Proteins by Human Macrophage Elastase

Theodore J. Gronski, Robert L. Martin, Dale K. Kobayashi et al. · Journal of Biological Chemistry · 1997 · 323 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

A continuous spectrophotometric assay for Clostridium histolyticum collagenase

Harold E. Van Wart, D. Randall Steinbrink · Analytical Biochemistry · 1981 · 255 citations

Life Sciences, Biochemistry, Microbiology +2

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)

Leif Dahlberg, R. Clark Billinghurst, Paul Manner et al. · Arthritis & Rheumatism · 2000 · 243 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17