C. Preston Neff

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

Carlo Marchetti, Benjamin J. Swartzwelter, Fabia Gamboni et al. · Proceedings of the National Academy of Sciences · 2018 · 559 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

Jiehua Zhou, Piotr Swiderski, Haitang Li et al. · Nucleic Acids Research · 2009 · 270 citations · Full text

Life Sciences, Molecular Biology, Molecular Pharmaceutics +17

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4 ⁺ T Cell Decline in Humanized Mice

C. Preston Neff, Jiehua Zhou, Leila Remling et al. · Science Translational Medicine · 2011 · 264 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

Suzhao Li, C. Preston Neff, Kristina Barber et al. · Proceedings of the National Academy of Sciences · 2015 · 230 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

Isak W. Tengesdal, Dinoop Ravindran Menon, Douglas G. Osborne et al. · Proceedings of the National Academy of Sciences · 2021 · 193 citations · Full text

Life Sciences, Immunology, Oncology +17