Jacob P. Mahoney

Conformational biosensors reveal GPCR signalling from endosomes

Roshanak Irannejad, Jin C. Tomshine, Jon R. Tomshine et al. · Nature · 2013 · 831 citations · Full text

G Protein-coupled Receptor, Natural Sciences, Endocytic Pathway +4

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

A. Thomsen, Bianca Plouffe, Thomas J. Cahill et al. · Cell · 2016 · 553 citations · Full text

Protein Function, Signal Transduction, Molecular Physiology +8

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

Brian T. DeVree, Jacob P. Mahoney, Gisselle A. Vélez-Ruiz et al. · Nature · 2016 · 294 citations · Full text

Molecular Pharmacology, Signal Transduction, Biochemistry +9

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

Anthony H. Nguyen, A. Thomsen, Thomas J. Cahill et al. · Nature Structural & Molecular Biology · 2019 · 218 citations · Full text

Protein Function, G Protein-coupled Receptor, Cellular Biochemistry +4

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Matthieu Masureel, Yaozhong Zou, Louis-Philippe Picard et al. · Nature Chemical Biology · 2018 · 196 citations · Full text

Molecular Pharmacology, Drug Target, G Protein-coupled Receptor +9