Rebecca T. Patterson

Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.

Laura G. Corral, Patrick Haslett, George W. Muller et al. · PubMed · 1999 · 731 citations

Medicine, Immunology, Pharmacology +17

Differential Cytokine Modulation and T Cell Activation by Two Distinct Classes of Thalidomide Analogues That Are Potent Inhibitors of TNF-α

Laura G. Corral, Patrick Haslett, George W. Muller et al. · The Journal of Immunology · 1999 · 654 citations · Full text

Medicine, Immunology, Pharmacology +16

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

George W. Muller, Roger Chen, Shaei‐Yun Huang et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 339 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7

Discovery of (<i>S</i>)-<i>N</i>-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1<i>H</i>-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Hon‐Wah Man, Peter Schäfer, Lu Min Wong et al. · Journal of Medicinal Chemistry · 2009 · 182 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Thalidomide analogs and PDE4 inhibition

George W. Muller, Mary G. Shire, Lu Min Wong et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 69 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +5