Toshiya Nishi

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Toshiya Nishi, Shinichi Kondo, Maki Miyamoto et al. · Scientific Reports · 2020 · 76 citations · Full text

Life Sciences, Neuroscience, Pharmacology +15

Soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice

Nicole A. Hawkins, Manuel Jurado, Tyler Thaxton et al. · Epilepsia · 2021 · 62 citations · Full text

Medicine, Neuroscience, Pharmacology +15

Analysis of Binding Sites for the New Small-Molecule CCR5 Antagonist TAK-220 on Human CCR5

Masao Nishikawa, Katsunori Takashima, Toshiya Nishi et al. · Antimicrobial Agents and Chemotherapy · 2005 · 61 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H)

Tatsuki Koike, Masato Yoshikawa, Haruhi Kamisaki Ando et al. · Journal of Medicinal Chemistry · 2021 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons

Xiaofei Wei, Toshiya Nishi, Shinichi Kondou et al. · Neuropharmacology · 2018 · 38 citations

Life Sciences, Neurobiology, Neuroscience +16