Joseph Chiesa

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

Teresa Coelho, David Adams, Ana Silva et al. · New England Journal of Medicine · 2013 · 947 citations · Full text

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

Kevin Fitzgerald, Maria Frank-Kamenetsky, Svetlana Shulga‐Morskaya et al. · The Lancet · 2013 · 571 citations · Full text

Metabolic Syndrome, Oxysterol, Biochemistry +9

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

Tracy Zimmermann, Verena Karsten, Amy Chan et al. · Molecular Therapy · 2017 · 202 citations · Full text

Safety, pharmacokinetics, pharmacogenomics and <scp>QT</scp> concentration−effect modelling of the <scp>SirT1</scp> inhibitor selisistat in healthy volunteers

Göran Westerberg, Joseph Chiesa, Claus A. Andersen et al. · British Journal of Clinical Pharmacology · 2014 · 58 citations · Full text

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects

Inge Lues, Frank Weber, Antje Meyer et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 2015 · 54 citations · Full text