T Sugimoto

<i>In silico</i> discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

Fumi Shima, Yoko Yoshikawa, Min Ye et al. · Proceedings of the National Academy of Sciences · 2013 · 292 citations · Full text

Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris.

Terushige Toyooka, Toru Aizawa, Nobuhiro Suzuki et al. · Circulation · 1991 · 247 citations · Full text

Thrombosis, Hypertension, Vascular Disease +15

On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel.

Hiroyuki Ito, Robert Tung, T Sugimoto et al. · The Journal of General Physiology · 1992 · 199 citations · Full text

Cellular Physiology, Atrial Cell Membrane, Molecular Pharmacology +20

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

Fumi Shima, Yuichi Ijiri, Shin Muraoka et al. · Journal of Biological Chemistry · 2010 · 150 citations · Full text

X-ray Crystallography, Conformational Dynamics, State Transition +14

Isolation of a urinary digitalis-like factor indistinguishable from digoxin

Atsuo Goto, Taro Ishiguro, Kaoru Yamada et al. · Biochemical and Biophysical Research Communications · 1990 · 137 citations

Urology, Biomedical Research, Bioanalysis +4