Jack A. Kauffman

Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.

Bruce E. Maryanoff, Xiayang Qiu, K. Padmanabhan et al. · Proceedings of the National Academy of Sciences · 1993 · 109 citations

Life Sciences, Biochemistry, Pharmacology +16

A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase

Lawrence de Garavilla, Michael N. Greco, N. Sukumar et al. · Journal of Biological Chemistry · 2005 · 93 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions

Bruce E. Maryanoff, Michael N. Greco, Han‐Cheng Zhang et al. · Journal of the American Chemical Society · 1995 · 87 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone

Michael J. Costanzo, Stephen C. Yabut, Harold R. Almond et al. · Journal of Medicinal Chemistry · 2003 · 82 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14

Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308

William J. Hoekstra, Bruce E. Maryanoff, Bruce P. Damiano et al. · Journal of Medicinal Chemistry · 1999 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16