Cris Brown

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

Simin Lu, Kohsuke Kanekura, Takashi Hara et al. · Proceedings of the National Academy of Sciences · 2014 · 148 citations · Full text

Calcium-dependent Protease, Apoptosis, Calpain 2 +25

Wolframin is a novel regulator of tau pathology and neurodegeneration

Shuo Chen, Diana Acosta, Liangping Li et al. · Acta Neuropathologica · 2022 · 42 citations

Neurodegenerative Diseases, Tau Pathology, Pathology +7

A phase 1b/2a clinical trial of dantrolene sodium in patients with Wolfram syndrome

Damien Abreu, Stephen Stone, Toni S. Pearson et al. · JCI Insight · 2021 · 37 citations · Full text

Electrolyte Disorder, Sodium Homeostasis, Inherited Metabolic Disease +11

Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome

Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye et al. · JCI Insight · 2022 · 29 citations · Full text

GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models

Vyron Gorgogietas, Bahareh Rajaei, Heeyoung Chae et al. · Diabetologia · 2023 · 28 citations · Full text