Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

Michael C. Schmid, Christie J. Avraamides, Holly C. Dippold, +12

Cancer Cell

InflammationCytokineImmune Cell DevelopmentReceptor Tyrosine KinaseImmune Regulation +9

Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth

Mingchuan Li, Valentina Sala, Maria Chiara De Santis, +30

Circulation

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

Irene Franco, Federico Gulluni, Carlo Cosimo Campa, +16

Developmental Cell

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging

Irene Franco, Anna Johansson, Karl Olsson, +11

Nature Communications

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

Federico Gulluni, Miriam Martini, Maria Chiara De Santis, +23

Cancer Cell

ChromatinChromatin StructureCell DivisionGenomic StabilityNatural Sciences +10

Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type

Irene Franco, Hafdís T. Helgadóttir, Aldo Moggio, +12

Genome biology

Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase γ Activity in Pressure Overload–Induced Cardiac Failure

Federico Damilano, Irene Franco, Cinzia Perrino, +9

Circulation

PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth

Michael C. Schmid, Irene Franco, Sang Won Kang, +3

PLoS ONE

Integrin ActivationCancer ResearchCancer ImmunosurveillanceCell RegulationMedicine +10

Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice

Federica Barutta, Séréna Grimaldi, Irene Franco, +10

Kidney International

Cannabis UseUrologyFunctional SelectivityMedicineStructural Abnormalities +9

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

Irene Franco, Jean Piero Margaria, Maria Chiara De Santis, +12

Journal of the American Society of Nephrology

Class IiPhosphoinositide 3-Kinase-c2αPrimary CiliumCellular PhysiologySignaling Pathway +16