Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives

Hao Chen, Guozhen Wu, Shuang Gao, +14

Journal of Medicinal Chemistry

Positive Compound 1Drug TargetChemoprevention StrategyImmunologyPeptide Science +24

Delavatine A, an unusual isoquinoline alkaloid exerts anti-inflammation on LPS-induced proinflammatory cytokines production by suppressing NF-κB activation in BV-2 microglia

Qing Xie, Guozhen Wu, Niao Yang, +3

Biochemical and Biophysical Research Communications

InflammationAnti-inflammatoryBv-2 MicrogliaMedicineImmune Regulation +10

Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic–Pituitary–Adrenal Axis Function and Activating BDNF Signaling Pathway

Xianpeng Zu, Wencai Li, Haisheng Xie, +4

Neurochemical Research

Hypothalamic–pituitary–adrenal Axis FunctionNeuroendocrinologySocial SciencesInflammationStress +15

Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways

Ziying Cheng, Yuan Xing, Yi Qu, +13

Cancer Letters

Tumor BiologyMedicineLiver PhysiologyPathologyCancer Cell Biology +6

Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production

Niao Yang, Rongcai Yue, Jinzhu Ma, +12

Pharmacological Research

InflammationCytokineAnti-inflammatory ActionAnti-inflammatoryAutoimmune Disease +10

Total sesquiterpene lactones isolated from Inula helenium L . attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice

Qun Wang, Shuang Gao, Guozhen Wu, +8

Phytomedicine

Inula Helenium LMedicinal ChemistryAtopic DermatitisTotal Sesquiterpene LactonesDermatitis-like Skin Lesions +7

Metabolism and pharmacokinetics of alantolactone and isoalantolactone in rats: Thiol conjugation as a potential metabolic pathway

Bailun Zhou, Ji Ye, Niao Yang, +11

Journal of Chromatography B

Potential Metabolic PathwayPharmacological StudyBiochemistryMedicinePhysiology +5

Simultaneous quantification of 11 active constituents in Shexiang Baoxin Pill by ultraperformance convergence chromatography combined with tandem mass spectrometry

Chao Lv, L. Q. Chen, Peng Fu, +8

Journal of Chromatography B

Pharmaceutical ScienceShexiang Baoxin PillBiochemistryGas ChromatographyMedicine +12

Cytotoxic and Anti‐inflammatory Sesquiterpenes from <i>Ainsliaea henryi</i>

Ren‐Tao Zeng, Xueyun Dong, Xing Fang, +5

Chemistry & Biodiversity

Lineariifolianoids I–L, four rare sesquiterpene lactone dimers inhibiting NO production from Inula lineariifolia

Liping Chen, Guozhen Wu, Hongyuan Dong, +3

RSC Advances

Lineariifolianoids I–lBiosynthesisBioorganic ChemistryEngineeringBiochemistry +12