Dirk Loeffler

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Eric M. Pietras, Cristina Mirantes-Barbeito, Sarah Fong et al. · Nature Cell Biology · 2016 · 677 citations

Inflammation, Developmental Biology, Bone Marrow Failure +13

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

Simon Haas, Jenny Hansson, Daniel Klimmeck et al. · Cell stem cell · 2015 · 475 citations · Full text

Inflammation, Cytokine, Granulocyte +11

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

Philipp S. Hoppe, Michael Schwarzfischer, Dirk Loeffler et al. · Nature · 2016 · 208 citations

Cell Lineage, Developmental Biology, Gata1 Protein Ratios +10

Prospective identification of hematopoietic lineage choice by deep learning

Felix Buggenthin, Florian Buettner, Philipp S. Hoppe et al. · Nature Methods · 2017 · 208 citations · Full text

Engineering, Genetics, Biomedical Data Science +5

Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells

Dirk Loeffler, Arne Wehling, Florin Schneiter et al. · Nature · 2019 · 184 citations · Full text

Cell Lineage, Medicine, Stem Cell Mobilization +6