Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery

Cesar Sommer, Hsin‐Yuan Cheng, Duy Nguyen, +9

Molecular Therapy

COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors

Anand Panchal, Pui Seto, Russell Wall, +13

mAbs

An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity

Yik A. Yeung, Veena Krishnamoorthy, Danielle Dettling, +13

Molecular Therapy

Rational Design and Synthesis of 4-((1<i>R</i>,2<i>R</i>)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

Jie Jack Li, Donna M. Iula, Maria Nguyen, +21

Journal of Medicinal Chemistry

Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production

Lain‐Yen Hu, Huangshu Lei, Daniel Du, +20

Bioorganic & Medicinal Chemistry Letters

Androgen Receptor AntagonistsHair GrowthMedicineSebum ProductionEndocrinology +2

Development of a long acting human growth hormone analog suitable for once a week dosing

Moorthy S. S. Palanki, Abhijit Bhat, Ben Bolaños, +10

Bioorganic & Medicinal Chemistry Letters

Growth HormoneHuman GrowthPhysiologyPharmacologyDevelopmental Endocrinology +4

(1 ,2 )-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production

Lain‐Yen Hu, Daniel Du, Jennifer K. Hoffman, +28

Bioorganic & Medicinal Chemistry Letters

Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort

Abhimanyu Garg, Sergio Fazio, P. Barton Duell, +10

Journal of the Endocrine Society

Regression of EGFR positive established solid tumors in mice with the conditionally active T cell engager TAK-186

Danielle Dettling, Eilene Kwok, Lucy Quach, +11

Journal for ImmunoTherapy of Cancer

Comprehensive mechanism-based antibody pharmacokinetic modeling

J Chabot, Danielle Dettling, Paul Jasper, +1

EngineeringImmunologyAntibody DistributionBiomedical EngineeringImmunotherapy +14