Ashraf Aboelela

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer

Benjamin J. Buckley, Ashraf Aboelela, Elahe Minaei et al. · Journal of Medicinal Chemistry · 2018 · 68 citations · Full text

6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease

Benjamin J. Buckley, Hiwa Majed, Ashraf Aboelela et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 26 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Biochemistry +13

Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors

Benjamin J. Buckley, Ashna A. Kumar, Ashraf Aboelela et al. · International Journal of Molecular Sciences · 2021 · 20 citations · Full text

A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis

Cara Adolph, Chen‐Yi Cheung, Matthew B. McNeil et al. · Cell chemical biology · 2023 · 18 citations · Full text

Dual-targeting Succinate Dehydrogenase, Pulmonary Tuberculosis, Biochemistry +7

Systematic evaluation of structure–property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride

Benjamin J. Buckley, Ashraf Aboelela, Hiwa Majed et al. · Bioorganic & Medicinal Chemistry · 2021 · 15 citations · Full text

Derivative (Chemistry), Pharmaceutical Chemistry, Engineering +6