Susan J. Harvey

Weight Loss Induced by Chronic Dapagliflozin Treatment Is Attenuated by Compensatory Hyperphagia in Diet‐Induced Obese (DIO) Rats

James J. Devenny, Helen E. Godonis, Susan J. Harvey et al. · Obesity · 2012 · 216 citations

Life Sciences, Endocrinology, Pharmacology +17

Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate

William N. Washburn, Mark C. Manfredi, Pratik Devasthale et al. · Journal of Medicinal Chemistry · 2014 · 20 citations

Pharmacy, Medicinal Chemistry, Pharmacology +8

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

Pratik Devasthale, Wei Wang, James Mignone et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 15 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2- <i>d</i> ]pyrimidin-4(3 <i>H</i> )-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor

Saleem Ahmad, William N. Washburn, Andrés S. Hernández et al. · Journal of Medicinal Chemistry · 2016 · 15 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Reductions in log P Improved Protein Binding and Clearance Predictions Enabling the Prospective Design of Cannabinoid Receptor (CB1) Antagonists with Desired Pharmacokinetic Properties

Bruce A. Ellsworth, Philip M. Sher, Ximao Wu et al. · Journal of Medicinal Chemistry · 2013 · 11 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16