Christine Jack

γ‐Secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in <i>Drosophila</i>

Craig A. Micchelli, William P. Esler, W. Taylor Kimberly et al. · The FASEB Journal · 2002 · 142 citations

Life Sciences, Neurobiology, Neuroscience +17

Aspartate Mutations in Presenilin and γ‐Secretase Inhibitors Both Impair Notch1 Proteolysis and Nuclear Translocation with Relative Preservation of Notch1 Signaling

Oksana Berezovska, Christine Jack, Pamela J. McLean et al. · Journal of Neurochemistry · 2000 · 119 citations

Life Sciences, Cell Biology, Molecular Biology +17

Notch1 and Amyloid Precursor Protein Are Competitive Substrates for Presenilin1-dependent γ-Secretase Cleavage

Oksana Berezovska, Christine Jack, Amy Deng et al. · Journal of Biological Chemistry · 2001 · 84 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Rapid Notch1 Nuclear Translocation after Ligand Binding Depends on Presenilin‐associated γ‐Secretase Activity

Oksana Berezovska, Christine Jack, Pamela J. McLean et al. · Annals of the New York Academy of Sciences · 2000 · 33 citations

Life Sciences, Cell Biology, Molecular Biology +15

Effect of PS1 deficiency and an APP γ-secretase inhibitor on Notch1 signaling in primary mammalian neurons

Christine Jack, Oksana Berezovska, Michael S. Wolfe et al. · Molecular Brain Research · 2001 · 25 citations

Life Sciences, Molecular Biology, Neuroscience +16