Christian C. Lee

The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer

Luc Friboulet, Nanxin Li, Ryohei Katayama et al. · Cancer Discovery · 2014 · 820 citations · Full text

Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-<i>N</i>2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-<i>N</i>4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Thomas H. Marsilje, Wei Pei, Bei Chen et al. · Journal of Medicinal Chemistry · 2013 · 405 citations · Full text

Chemoprevention Strategy, Pharmacotherapy, Structure–activity Relationships +21

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain

Christian C. Lee, Yong Jia, Nanxin Li et al. · Biochemical Journal · 2010 · 175 citations

Crystal Structure of the Human Neuropilin-1 b1 Domain

Christian C. Lee, Andreas Kreusch, Daniel McMullan et al. · Structure · 2003 · 94 citations · Full text

Crystal Structure, Protein Function, Protein X-ray Crystallography +3

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2

Ha-Soon Choi, Zhicheng Wang, Wendy Richmond et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 55 citations

Combinatorial Chemistry, Medicinal Chemistry, Pharmaceutical Science +7