Dai Kubota

Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 2: Synthesis of potent αvβ3/αIIbβ3 dual antagonists

Minoru Ishikawa, Dai Kubota, Mikio Yamamoto et al. · Bioorganic & Medicinal Chemistry · 2005 · 40 citations

Molecular Pharmacology, Medicinal Chemistry, Tricyclic Pharmacophore-based Molecules +6

Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part III: Synthesis of potent antagonists with αvβ3/αIIbβ3 dual activity and improved water solubility

Minoru Ishikawa, Yukiko Hiraiwa, Dai Kubota et al. · Bioorganic & Medicinal Chemistry · 2005 · 40 citations

Molecular Pharmacology, Medicinal Chemistry, Tricyclic Pharmacophore-based Molecules +9

Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting αvβ3/αIIbβ3 dual antagonistic activity

Dai Kubota, Minoru Ishikawa, Mikio Yamamoto et al. · Bioorganic & Medicinal Chemistry · 2005 · 27 citations

Molecular Pharmacology, Medicinal Chemistry, Tricyclic Pharmacophore-based Molecules +8

Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part IV: Preliminary control of αvβ3 selectivity by meta-oriented substitution

Dai Kubota, Minoru Ishikawa, Midori Ishikawa et al. · Bioorganic & Medicinal Chemistry · 2006 · 16 citations

Molecular Pharmacology, Medicinal Chemistry, αVβ3 Selectivity +9

A Scalable Synthesis of MN-447, an Antagonist for Integrins α_vβ₃ and α_IIbβ₃

Minoru Ishikawa, Masaki Tsushima, Dai Kubota et al. · Organic Process Research & Development · 2008 · 14 citations

Molecular Pharmacology, Medicinal Chemistry, Synthetic Strategies +15