Michael B. Dilling

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

Hajime Hosoi, Michael B. Dilling, Takuma Shikata et al. · PubMed · 1999 · 316 citations

Apoptosis, Cell Death, Cell Proliferation +23

Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition.

Lorina Dudkin, Michael B. Dilling, Pamela J. Cheshire et al. · PubMed · 2001 · 232 citations

Chemoprevention Strategy, Cancer Biology, Tumor Biology +19

Sustained Activation of the JNK Cascade and Rapamycin-Induced Apoptosis Are Suppressed by p53/p21Cip1

Shile Huang, Lili Shu, Michael B. Dilling et al. · Molecular Cell · 2003 · 220 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +10

Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells

Hajime Hosoi, Michael B. Dilling, Linda N. Liu et al. · Molecular Pharmacology · 1998 · 172 citations

Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor.

Michael B. Dilling, Peter Dias, David N. Shapiro et al. · PubMed · 1994 · 135 citations

Immunology, Cell Proliferation, Cell Growth +16