AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Jacqueline H. L. Fok, Antonio Ramos‐Montoya, Mercedes Vázquez–Chantada, +22

Nature Communications

Sulfate Metabolites Provide an Intracellular Pool for Resveratrol Generation and Induce Autophagy with Senescence

Ketan Patel, Catherine Andreadi, Robert G. Britton, +9

Science Translational Medicine

MitophagyNutraceutical IngredientLipid PeroxidationCell DeathFree Resveratrol +18

Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

Mark I. James, Chinenye Iwuji, Glen R.B. Irving, +16

Cancer Letters

Chemoprevention StrategyMedicineCancer Stem CellPharmacologyFolfox Chemotherapy +11

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

Hong Cai, Edwina N. Scott, Abeer Othman A. Kholghi, +21

Science Translational Medicine

Chemoprevention StrategyOxidative StressOncologyAnti-cancer AgentResveratrol Ex Vivo +15

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

Constantia Alexandrou, Saif Sattar Al-Aqbi, Jennifer A. Higgins, +13

Scientific Reports

In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer

María Ángeles Núñez‐Sánchez, Ankur Karmokar, Antonio González‐Sarrías, +5

Food and Chemical Toxicology

MedicinePharmacologyNew PotentialityColorectal CancerAnti-cancer Agent +4

Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control

Kyoko Nakamura, Ankur Karmokar, Paul Farrington, +9

Clinical Cancer Research

The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

Elizabeth Hardaker, Emilio Sanseviero, Ankur Karmokar, +53

Nature Communications

Optimization of an Imidazo[1,2-<i>a</i>]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with <i>In Vivo</i> Efficacy

William McCoull, Scott Boyd, Martin R. Brown, +41

Journal of Medicinal Chemistry

Dietary intake of rosmarinic acid by <i>Apc^Min</i> mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development

Ankur Karmokar, Timothy H. Marczylo, Hong Cai, +3

Molecular Nutrition & Food Research