Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy

Jumin Huang, Di Liu, Yuwei Wang, +31

Gut

Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer

Zebo Jiang, Wenjun Wang, Cong Xu, +14

Cancer Letters

Derivative ApigeninMedicineOncogenic AgentImmunologyTumor Immunity +8

Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis

Zebo Jiang, Jumin Huang, Ya‐Jia Xie, +10

Journal of Experimental & Clinical Cancer Research

Metabolomics and integrated network pharmacology analysis reveal Tricin as the active anti-cancer component of Weijing decoction by suppression of PRKCA and sphingolipid signaling

Jiaxin Li, Runze Li, Ao Sun, +17

Pharmacological Research

Chemoprevention StrategyBiochemistryMedicineSphingolipid SignalingMetabolomic Profiling +7

β-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer

Cong Xu, Zebo Jiang, Le Shao, +13

Pharmacological Research

Chemoprevention StrategyCancer BiologyTumor BiologyMetronomic TherapyCancer Cell Biology +14

Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

Xiaoqing Fan, Chu-Tian Mai, Ling Zuo, +12

Acta Pharmaceutica Sinica B

Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species

Zepeng Qu, Hongbin Liu, Yang Ji, +16

Nature Communications

Dolutegravir derivative inhibits proliferation and induces apoptosis of non-small cell lung cancer cells via calcium signaling pathway

Wenjun Wang, Longfei Mao, Huanling Lai, +10

Pharmacological Research

Oncogenic AgentMedicineInduces ApoptosisImmunologyCell Death +4

Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8+ T cells

Zebo Jiang, Cong Xu, Wenjun Wang, +12

Pharmacological Research

OncologyMedicineImmunologyCd8+ T CellsTumor Suppressor +5

Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening

Qianqian Wang, Jiahui Xu, Ying Li, +6

Frontiers in Pharmacology

Drug TargetEngineeringMolecular BiologyPrmt5 InhibitorTumor Biology +19