Nadia L. Mitchell

Longitudinal In Vivo Monitoring of the CNS Demonstrates the Efficacy of Gene Therapy in a Sheep Model of CLN5 Batten Disease

Nadia L. Mitchell, Katharina N. Russell, Martin Wellby et al. · Molecular Therapy · 2018 · 94 citations · Full text

Medicine, Neurobiology, Neuroscience +12

A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in Merino sheep whereas affected South Hampshire sheep have reduced levels of CLN6 mRNA

Imke Tammen, Peter J. Houweling, Tony Frugier et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2006 · 76 citations

Veterinary Medicine, Animal Sciences, Pathobiology +6

A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571 + 1G >>> A) leading to excision of exon 3

Tony Frugier, Nadia L. Mitchell, Imke Tammen et al. · Neurobiology of Disease · 2007 · 75 citations · Full text

Veterinary Medicine, Molecular Genetics, Pathobiology +6

Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses

Katharina N. Russell, Nadia L. Mitchell, Nigel Anderson et al. · Brain and Behavior · 2018 · 51 citations · Full text

Life Sciences, Neurology, Neuroscience +13

Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep

Nicholas Perentos, Amadeu Quelhas Martins, Thomas C. Watson et al. · Brain · 2015 · 45 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17