Concepedia

Author

Nicolas Sprynski

University of SienaORCID

Also Known As

Nicolas Sprynski

11

Publications

369

Citations

9

H-Index

19

Concepts

All Affiliations

University of SienaCharles River Laboratories (United Kingdom)
NS

About

Nicolas Sprynski is an author at University of Siena specializing in infection control, microbiology, and medicine.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

3

3

116

2

Microbiology

3

3

116

3

Health Sciences

2

2

96

4

Pharmacology

2

2

96

5

Antibiotics

2

2

96

Nicolas Sprynski

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9

Publications

362

Citations

9

H-Index

YearCitations

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

Martin Everett, Nicolas Sprynski, Alicia Coelho,

Antimicrobial Agents and Chemotherapy

2018

94

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

Simon Leiris, Alicia Coelho, Jérôme Castandet,

ACS Infectious Diseases

2018

53

ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing <i>Enterobacteriaceae</i>

David T. Davies, Simon Leiris, Nicolas Sprynski,

ACS Infectious Diseases

2020

43

Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model

Cristina Cigana, Jérôme Castandet, Nicolas Sprynski,

Frontiers in Microbiology

2021

41

Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive <i>Enterobacterales</i>

Magdalena Zalacaín, Clarisse Lozano, Agustina Llanos,

Antimicrobial Agents and Chemotherapy

2021

35

Discovery of <b>ANT3310</b>, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and <i>Acinetobacter baumannii</i>

David T. Davies, Simon Leiris, Magdalena Zalacaín,

Journal of Medicinal Chemistry

2020

34

Chemical Optimization of Selective <i>Pseudomonas aeruginosa</i> LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

Martin Everett, David T. Davies, Simon Leiris,

ACS Infectious Diseases

2023

28

Galleria mellonella as an Infection Model for Select Agents

Nicolas Sprynski, Eric Valade, Fabienne Neulat-Ripoll

Methods in molecular biology

2014

20

Virtual Screening Approach to Identifying a Novel and Tractable Series of<i>Pseudomonas aeruginosa</i>Elastase Inhibitors

Simon Leiris, David T. Davies, Nicolas Sprynski,

ACS Medicinal Chemistry Letters

2021

14

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