Simon Leiris

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

Martin Everett, Nicolas Sprynski, Alicia Coelho et al. · Antimicrobial Agents and Chemotherapy · 2018 · 95 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +17

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

Simon Leiris, Alicia Coelho, Jérôme Castandet et al. · ACS Infectious Diseases · 2018 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing <i>Enterobacteriaceae</i>

David T. Davies, Simon Leiris, Nicolas Sprynski et al. · ACS Infectious Diseases · 2020 · 45 citations

Pharmacy, Pharmacology, Pharmacotherapy +17

Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive <i>Enterobacterales</i>

Magdalena Zalacaín, Clarisse Lozano, Agustina Llanos et al. · Antimicrobial Agents and Chemotherapy · 2021 · 38 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

Discovery of <b>ANT3310</b>, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and <i>Acinetobacter baumannii</i>

David T. Davies, Simon Leiris, Magdalena Zalacaín et al. · Journal of Medicinal Chemistry · 2020 · 36 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17