CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

François Ghiringhelli, Nicolas Larmonier, E. Schmitt, +7

European Journal of Immunology

T-regulatory CellImmunologyImmune RegulationImmunoeditingRegulatory T Cells +18

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4 <b>+</b> CD25 <b>+</b> regulatory T cell proliferation

François Ghiringhelli, Pierre E. Puig, S. Roux, +7

The Journal of Experimental Medicine

HSP27 Is a Ubiquitin-Binding Protein Involved in I-κBα Proteasomal Degradation

Arnaud Parcellier, E. Schmitt, Sandeep Gurbuxani, +7

Molecular and Cellular Biology

ApoptosisImmunologyProteasomeCell DeathSignaling Pathway +14

Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor

Sandeep Gurbuxani, E. Schmitt, Céline Candé, +8

Oncogene

Nuclear ImportSignal TransductionProtein FunctionApoptosisApoptosis-inducing Factor +6

HSP27 and HSP70: Potentially Oncogenic Apoptosis Inhibitors

Carmen Garrido, E. Schmitt, Céline Candé, +3

Cell Cycle

Powerful ChaperonesReductive StressOncogenic AgentApoptosisImmunology +9

HSP27 favors ubiquitination and proteasomal degradation of p27 ^Kip1 and helps S‐phase re‐entry in stressed cells

Arnaud Parcellier, Mathilde Brunet, E. Schmitt, +17

The FASEB Journal

Molecular RegulationApoptosisProteasomeMolecular BiologyCell Death +18

Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells

Sandeep Gurbuxani, Jean-Marie Bruey, Annie Fromentin, +6

Oncogene

Tumor BiologyCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +8

Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.

E. Schmitt, Arnaud Parcellier, Sandeep Gurbuxani, +12

PubMed

Molecular RegulationApoptosisImmunologyCell DeathMolecular Biology +15

In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

Banu Sürücü, Lana Bozulic, Debby Hynx, +2

Journal of Biological Chemistry

Cell DeathMolecular BiologyDna-dependent Protein KinaseFull ActivationTumor Biology +16

Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis

Arnaud Parcellier, Lionel Tintignac, Elena Zhuravleva, +4

Cellular Signalling

MitophagySignal TransductionMitochondrial FunctionApoptosisCell Death +7