Microbial Genomics as a Guide to Drug Discovery and Structural Elucidation:  ECO-02301, a Novel Antifungal Agent, as an Example

James B. McAlpine, Brian O. Bachmann, Mahmood Piraee, +4

Journal of Natural Products

Novel AntibioticsHplc ProfilesDrug ResistanceBiosynthesisNatural Product Biosynthesis +14

The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene The GenBank accession number for the sequence reported in this paper is AF262220.

Jing He, Nathan A. Magarvey, Mahmood Piraee, +1

Microbiology

Genomic Analyses Lead to Novel Secondary Metabolites

Arjun H. Banskota, James B. McAlpine, Dan Sørensen, +6

The Journal of Antibiotics

Novel Secondary MetabolitesGeneticsMetabolomic ProfilingMetabolic ProfilingMetabolomics +3

Isolation and Identification of Three New 5-Alkenyl-3,3(2H)-furanones from Two Streptomyces species using a Genomic Screening Approach

Arjun H. Banskota, James B. McAlpine, Dan Sørensen, +7

The Journal of Antibiotics

Genomic Screening ApproachBiosynthesisBiochemistryNatural Product BiosynthesisThree New 5-Alkenyl-3,3 +2

Biosynthesis of Diazepinomicin/ECO-4601, a <i>Micromonospora</i> Secondary Metabolite with a Novel Ring System

James B. McAlpine, Arjun H. Banskota, Romila D. Charan, +10

Journal of Natural Products

Medicinal ChemistryBiosynthesisEngineeringBiotransformationBiochemistry +12

Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

Matthew A. Gregory, Michael Bobardt, Susan Obeid, +14

Antimicrobial Agents and Chemotherapy

Biosynthesis of the dichloroacetyl component of chloramphenicol in Streptomyces venezuelae ISP5230: genes required for halogenation

Mahmood Piraee, Robert L. White, L. C. Vining

Microbiology

Conjugal TransferBiosynthesisCm BiosynthesisEngineeringBiochemistry +11

Effects of Yerba maté, a Plant Extract Formulation (“YGD”) and Resveratrol in 3T3-L1 Adipogenesis

Juliana C. Santos, Érica Martins Ferreira Gotardo, Mitsue Taukeuti Brianti, +3

Molecules

Yerba MateMetabolic RemodelingInsulin SignalingPolyphenolicsMetabolic Syndrome +14

Use of degenerate primers and touchdown PCR to amplify a halogenase gene fragment from Streptomyces venezuelae ISP5230

Mahmood Piraee, L. C. Vining

Journal of Industrial Microbiology & Biotechnology

TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins

Arjun H. Banskota, Mustapha Aouidate, Dan Sørensen, +9

The Journal of Antibiotics

New Echinosporamicin-type AntibioticsAntibioticsBiochemistryMedicineNatural Sciences +9