Secreted Frizzled-Related Protein-1 Inhibits RANKL-Dependent Osteoclast Formation

K D Hausler, Nicole J. Horwood, Yoshiro Chuman, +5

Journal of Bone and Mineral Research

Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors

Satoshi Osada, Satoshi Sano, Mariko Ueyama, +3

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceFluoroalkene ModificationMedicineNatural Sciences +6

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling

Charles P. Xavier, Maria Melikova, Yoshiro Chuman, +3

Cellular Signalling

Developmental BiologySignal TransductionSignaling PathwayMolecular RegulationMedicine +4

Highly Potent Nociceptin Analog Containing the Arg-Lys Triple Repeat

Kazushi Okada, Tetsujo Sujaku, Yoshiro Chuman, +7

Biochemical and Biophysical Research Communications

Molecular PharmacologyMedicinal ChemistryPain MedicineMedicineNeuropathic Pain +8

Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells

MV Blagosklonny, Yoshiro Chuman, Tito Fojo

Leukemia

Cell RegulationApoptosisCell DeathLeukemia CellsAnti-cancer Agent +5

Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix[6]arene derivatives

Rui Kamada, Wataru Yoshino, Takao Nomura, +4

Bioorganic & Medicinal Chemistry Letters

Tumor BiologyTetramer FormationMedicineOncogenic AgentCell Biology +5

PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression

Yoshiro Chuman, Wataru Kurihashi, Y. Mizukami, +3

The Journal of Biochemistry

SpermatogenesisTranscriptional RegulationGenome InstabilityMedicineGenetics +9

A small molecule inhibitor of p53-inducible protein phosphatase PPM1D

Hiroaki Yagi, Yoshiro Chuman, Yuuki Kozakai, +5

Bioorganic & Medicinal Chemistry Letters

BiochemistryMolecular PathwayNatural SciencesMolecular BiologySmall Molecule Inhibitor +3

sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration

Gema Martin‐Manso, Marı́a J. Calzada, Yoshiro Chuman, +5

Archives of Biochemistry and Biophysics

Signal TransductionSignaling PathwayCell SignalingCell AdhesionCell-matrix Interaction +10

Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation

Sari Ogasawara, Yuhei Kiyota, Yoshiro Chuman, +5

Bioorganic & Medicinal Chemistry

Tumor BiologyPpm1d PhosphataseMedicinePharmacologyCell Death +7