Yiwu Yao

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

Shirish Shukla, Weijiang Ying, Felicia Gray et al. · Nature Chemical Biology · 2021 · 64 citations · Full text

Natural Sciences, Medicine, Ring Domain +6

Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities

Yiwu Yao, Zhengchao Tu, Chenzhong Liao et al. · Journal of Medicinal Chemistry · 2015 · 60 citations · Full text

Histone Modifications, Compound 13, Tumor Biology +17

Total synthesis of securinega alkaloids (−)-norsecurinine, (−)-niruroidine and (−)-flueggine A

Nan Ma, Yiwu Yao, Bing‐Xin Zhao et al. · Chemical Communications · 2014 · 59 citations

Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors

Yiwu Yao, Chenzhong Liao, Zheng Li et al. · European Journal of Medicinal Chemistry · 2014 · 59 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +12

Structure-Based Design of a Selective Class I Histone Deacetylase (HDAC) Near-Infrared (NIR) Probe for Epigenetic Regulation Detection in Triple-Negative Breast Cancer (TNBC)

Kuojun Zhang, Zhiyi Liu, Yiwu Yao et al. · Journal of Medicinal Chemistry · 2021 · 45 citations · Full text