Theresa J. O’Sullivan

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 446 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors

Antonia F. Stepan, Kapil Karki, W. Scott McDonald et al. · Journal of Medicinal Chemistry · 2011 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid:  Discovery of a Novel Aminoguanidinoacetic Acid Antidiabetic Agent

Scott D. Larsen, Mark A. Connell, Michele M. Cudahy et al. · Journal of Medicinal Chemistry · 2001 · 70 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity

B.C. Finzel, Eric T. Baldwin, G. L. Bryant et al. · Protein Science · 1998 · 69 citations

Life Sciences, Biochemistry, Medicinal Chemistry +17

Synthesis and Biological Activity of a Novel Class of Small Molecular Weight Peptidomimetic Competitive Inhibitors of Protein Tyrosine Phosphatase 1B

Scott D. Larsen, Tjeerd Barf, Charlotta Liljebris et al. · Journal of Medicinal Chemistry · 2001 · 64 citations

Medicine, Medicinal Chemistry, Pharmacology +16