Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

Jo Lynne Rokita, Komal S. Rathi, Maria Cardenas, +66

Cell Reports

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

Patrick Sin‐Chan, Iqra Mumal, Tannu Suwal, +51

Cancer Cell

GliomaOncogenic AgentMedicineHijacked Super-enhancersDistinct Therapeutic Vulnerability +5

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Jena Lilly, Jo Lynne Rokita, Jennifer L. Mason, +97

Neoplasia

Systems biology–based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma

Lei Huang, Sarah G. Injac, Kemi Cui, +14

Science Translational Medicine

Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors

Frank Y. Lin, Austin J. Stuckert, Candise Tat, +30

Journal of Clinical Oncology

c-Fos over-expression promotes radioresistance and predicts poor prognosis in malignant glioma

Zhi-Gang Liu, Guanmin Jiang, Jiao Tang, +11

Oncotarget

PathologyHigh-grade GliomasCell DifferentiationRadiation BiologyCancer Biology +16

Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study

Sara Khan, Palma Solano‐Páez, Tannu Suwal, +133

The Lancet Child & Adolescent Health

Multi-layered RosettesNeuro-oncologyTumoral PathologyGliomaTumor Heterogeneity +9

Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models

Mari Kogiso, Lin Qi, Frank Braun, +15

Clinical Cancer Research

Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group

Lindsey M. Hoffman, Camilo Jaimes, Kshitij Mankad, +21

Neuro-Oncology

Germline <i>POLE</i> mutation in a child with hypermutated medulloblastoma and features of constitutional mismatch repair deficiency

Holly Lindsay, Sarah Scollon, Jacquelyn Reuther, +9

Molecular Case Studies