Mado Nakajima

Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides

Takeshi Kasuya, Shinichiro Hori, Ayahisa Watanabe et al. · Scientific Reports · 2016 · 109 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

Akane Kamiyama, Mado Nakajima, Liyou Han et al. · Bioorganic & Medicinal Chemistry · 2016 · 37 citations

Life Sciences, Biochemistry, Medicinal Chemistry +9

Glutathione-analogous peptidyl phosphorus esters as mechanism-based inhibitors of γ-glutamyl transpeptidase for probing cysteinyl-glycine binding site

Mado Nakajima, Bunta Watanabe, Liyou Han et al. · Bioorganic & Medicinal Chemistry · 2013 · 28 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +8

Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B

Ayahisa Watanabe, Mado Nakajima, Naohisa Kitade et al. · Journal of Pharmacology and Experimental Therapeutics · 2016 · 27 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

[3H]S-145 and [125I]I-S-145-OH: new radioligands for platelet thromboxane A2 receptor with low nonspecific binding and high binding affinity for various receptor preparations.

Fumitaka Ushikubi, Mado Nakajima, Keigo Ohtsu et al. · PubMed · 1989 · 19 citations

Medicine, Chemistry, Pharmacology +16