John Fielden

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Bruno Vaz, Marta Popović, J.A. Newman et al. · Molecular Cell · 2016 · 246 citations · Full text

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

John Fielden, Katherine Wiseman, Ignacio Torrecilla et al. · Nature Communications · 2020 · 98 citations · Full text

The p97–Ataxin 3 complex regulates homeostasis of the <scp>DNA</scp> damage response E3 ubiquitin ligase <scp>RNF</scp> 8

Abhay Narayan Singh, Judith Oehler, Ignacio Torrecilla et al. · The EMBO Journal · 2019 · 60 citations · Full text

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter et al. · Nature Communications · 2019 · 45 citations · Full text

Comprehensive interrogation of synthetic lethality in the DNA damage response

John Fielden, Sebastian M. Siegner, Danielle N. Gallagher et al. · Nature · 2025 · 35 citations · Full text