Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia

C. Joana Marques, Paulo Costa, Bruno Vaz, +4

Molecular Human Reproduction

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Bruno Vaz, Marta Popović, J.A. Newman, +15

Molecular Cell

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

Davor Lessel, Bruno Vaz, Swagata Halder, +33

Nature Genetics

HepatologyMedicineGeneticsPathologyCancer Genomics +7

An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory

Alessio Lanna, Bruno Vaz, Clara D’Ambra, +12

Nature Cell Biology

Intercellular TransferT-regulatory CellImmunologyCellular SenescenceAutoimmunity +4

A UV-sensitive syndrome patient with a specific <i>CSA</i> mutation reveals separable roles for CSA in response to UV and oxidative DNA damage

Tiziana Nardò, Roberta Oneda, Graciela Spivak, +9

Proceedings of the National Academy of Sciences

Uv-sensitive Syndrome PatientDna DamageGeneticsMolecular BiologyCsa Gene +15

An altered redox balance mediates the hypersensitivity of Cockayne syndrome primary fibroblasts to oxidative stress

Barbara Pascucci, Tiziana Lemma, Egidio Iorio, +13

Aging Cell

Primary FibroblastsLipid PeroxidationCockayne SyndromeRedox BiologyOxidative Stress +15

Role of p97/VCP (Cdc48) in genome stability

Bruno Vaz, Swagata Halder, Kristijan Ramadan

Frontiers in Genetics

Genomic MechanismMolecular BiologyMolecular GeneticsGenome StabilityOwn Atpase Hydrolysis +15

The p97–Ataxin 3 complex regulates homeostasis of the <scp>DNA</scp> damage response E3 ubiquitin ligase <scp>RNF</scp> 8

Abhay Narayan Singh, Judith Oehler, Ignacio Torrecilla, +16

The EMBO Journal

The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

Annamaria Ruggiano, Bruno Vaz, Susan Kilgas, +6

Cell Reports

GeneticsProteasomeMolecular BiologyDpc FormationGenomic Mechanism +16

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication

Swagata Halder, Ignacio Torrecilla, Martin D. Burkhalter, +12

Nature Communications