Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

Michio Nakaya, Kenji Watari, Mitsuru Tajima, +18

Journal of Clinical Investigation

Cardiac MuscleHeart FailureEngineeringImmunologyCell Death +19

Multiple functions of G protein-coupled receptor kinases

Kenji Watari, Michio Nakaya, Hitoshi Kurose

Journal of Molecular Signaling

Molecular PharmacologySignal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled Receptor +13

Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa

Yasuhiko Hirami, Michiko Mandai, Sunao Sugita, +27

Cell stem cell

Regenerative MedicineOcular DiseaseRetinaOphthalmologyExperimental Ophthalmology +9

Induction of Cardiac Fibrosis by β-Blocker in G Protein-independent and G Protein-coupled Receptor Kinase 5/β-Arrestin2-dependent Signaling Pathways

Michio Nakaya, Satsuki Chikura, Kenji Watari, +9

Journal of Biological Chemistry

Cardiac MuscleG Protein-independentCardiovascular PharmacologyPharmacotherapyMolecular Pharmacology +17

β-arrestin2 in Infiltrated Macrophages Inhibits Excessive Inflammation after Myocardial Infarction

Kenji Watari, Michio Nakaya, Motohiro Nishida, +2

PLoS ONE

InflammationInflammatory ResponsesCytokineSignal TransductionMolecular Physiology +13

Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction

Hayato Fukuda, Saki Ito, Kenji Watari, +5

ACS Medicinal Chemistry Letters

Heart FailureDrug LeadPharmacotherapyCoronary Artery DiseaseAcute Myocardial Infarction +14

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Michio Nakaya, Mitsuru Tajima, Hidetaka Kosako, +15

Nature Communications

Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy

Kenji Watari, Suguru Yamasaki, Hung‐Ya Tu, +29

Communications Biology

Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue

Atsushi Kuwahara, Suguru Yamasaki, Michiko Mandai, +11

Scientific Reports

GRK6 phosphorylates IκBα at Ser32/Ser36 and enhances TNF-α-induced inflammation

Yuki Ohba, Michio Nakaya, Kenji Watari, +2

Biochemical and Biophysical Research Communications

InflammationCytokineSignal TransductionImmunologyImmune Regulation +5